In the coulometric-amperometric method for chloride measurement, how is the amount of chloride assessed?

In the coulometric-amperometric method for chloride measurement, the quantification of chloride ions is based on the time needed to reach the titration endpoint. This method involves the generation of silver ions from a silver electrode through electrolysis in the presence of chloride ions. Chloride ions react with the generated silver to form precipitate until all chloride is consumed. The endpoint is reached when there is a detectable change in current, indicating that all chloride has reacted.

The time it takes for the system to detect this endpoint allows for the calculation of the concentration of chloride ions present in the sample, as it is proportional to the amount of silver that was required to react with the chloride ions. This approach provides a precise measurement of chloride levels based on the electrical properties of the reaction, making it an effective analytical technique in clinical and laboratory settings.